Spurs duo Lamela and Sissoko among many first-teamers missing AC Milan clash

Tottenham Hotspur's Erik Lamela (centre) shares a joke with team-mates (pic: Gareth Fuller/PA Images

Tottenham Hotspur's Erik Lamela (centre) shares a joke with team-mates (pic: Gareth Fuller/PA Images). - Credit: PA Wire/PA Images

The Lilywhites will have to field another weakened side for the final game in the International Champions Cup

Spurs will be without a number of players for their final match in the United States against AC Milan in the early hours of Wednesday morning (UK time).

Tottenham Hotspur take on the Serie A giants in Minneapolis for a 7.35pm kick-off local time.

It is the final match of the International Champions Cup, but Mauricio Pochettino will not be able to call upon various first-team players.

He told the official club website: “Erik (Lamela) and Moussa (Sissoko) are not going to play.

“We hope it is not a big issue and that is why they are here with us, but it makes no sense to take any risks with them.

“Victor Wanyama has gone back to London for a scan (on his knee), so that is the situation.”

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In addition to Lamela, Sissoko and Wanyama, Spurs will be without Tashan Oakley-Boothe either after he returned to Hotspur Way for treatment.

Juan Foyth was due to fly out with the squad to the United States, but suffered a thigh injury in a behind closed doors friendly with Brentford on July 21 and will now miss the start of the Premier League season.

Elsewhere, Harry Winks is already on the treatment table after continuing his rehab following ankle surgery and Josh Onomah is in England working his way back to full fitness after a knee injury.

This is in addition to Harry Kane, Dele Alli, Eric Dier, Danny Rose, Kieran Trippier, Jan Vertonghen, Mousa Dembele, Toby Alderweireld and Hugo Lloris being away on holidays and getting a well-deserved break after success at the World Cup.

It means Pochettino will have to select an even weaker starting XI than normal to take on AC Milan.

Youngsters Luke Amos, 21, and 17-year-old Oliver Skipp are set to start in the centre of midfield while Davinson Sanchez could make his first start of the summer.

Elsewhere, the likes of Fernando Llorente, Christian Eriksen, Heung-min Son and Lucas Moura will make up the attacking quartet.

In defence, Serge Aurier, Cameron Carter-Vickers and Ben Davies will most likely join Sanchez in defence and one of Michel Vorm or Paulo Gazzaniga will start in goal.