Tottenham Hotspur will have to try and beat the Eredivisie champions without Lloris, Rose, Vertonghen, Dier, Wanyama and Dembele

Spurs’ squad depth will be tested once again on Tuesday night when they host PSV in Group B of the Champions League without eight first-team players.

Juan Foyth and Georges-Kevin Nkoudou are not able to feature because they were not included in the Tottenham Hotspur’s European squad list due to a lack of spaces.

Both appeared in the 3-1 win at West Ham United last Wednesday in the League Cup, while Foyth also started in the 3-2 victory away to Wolverhampton Wanderers last weekend in the Premier League.

In addition to the pair, more regular starting players Hugo Lloris, Danny Rose, Jan Vertonghen, Eric Dier, Victor Wanyama and Mousa Dembele are unavailable.

Lloris will serve a one-match ban following his red card in the 2-2 draw at PSV on October 24, so one of Paulo Gazzaniga or Michel Vorm will deputise.

Rose and Vertonghen remain on the sidelines with groin and hamstring issues and the club revealed last week they will not return until after the international break.

Dier, who has a thigh problem, will also not feature for Spurs until November 24 at the earliest when they host Chelsea in the league at Wembley Stadium.

There is better news for Wanyama, however, who is struggling with his knee, but may be able to return for Saturday’s trip to Crystal Palace.

He is definitely out of this week’s European clash, though, and so is Dembele after he was forced off in the early exchanges of the win at Wolves.

The Belgian suffered an ankle injury and will not face PSV and Mauricio Pochettino will probably have to select Harry Winks and Moussa Sissoko in midfield again.

Alternatively, he could drop Christian Eriksen into a deeper role and play the likes of Dele Alli, Heung-min Son and one of Lucas Moura or Erik Lamela behind Harry Kane.

While Spurs have a plethora of injuries, a number of fringe players have stepped up to the mark of late and they may need to do the same again if Tottenham are to secure a maiden win in this season’s competition on Tuesday and keep alive their hopes of progressing from Group B.