Mauricio Pochettino is set to select a strong starting XI for the London derby

Tottenham Hotspur are expected to make a number of changes for tonight’s League Cup fourth round tie at West Ham United, but Mauricio Pochettino should still put out a strong starting XI.

At lunchtime, the club confirmed Eric Dier would miss the derby due to a thigh strain picked up in Monday’s 1-0 loss to Premier League champions Manchester City.

Dier’s absence will be a blow to Pochettino with Spurs lacking options at centre back because Jan Vertonghen remains injured with a hamstring problem.

Left-back Danny Rose continues to be troubled by a groin issue too and so he will not play at the London Stadium.

It means Serge Aurier and Kyle Walker-Peters should line-up at full-back while Spurs may have to play defender Davinson Sanchez again despite him starting on Monday.

Centre back Juan Foyth could get a call in from the cold as well after failing to feature for the club this season.

Pochettino will most likely select a strong midfield after Harry Winks, Christian Eriksen, Dele Alli and Heung-min Son were all on the bench for Tottenham at the start of this week.

Winks, Eriksen and Alli were introduced against City and the trio are predicted to be included from the off for this last-16 tie tonight.

Victor Wanyama will probably feature too and up front could be Fernando Llorente, but Tottenham may name a strong bench with Toby Alderweireld and Harry Kane set to be among the replacements.

They could be joined by youngster Oliver Skipp, who has impressed this season after a strong summer in the United States with the first-team.

Hugo Lloris starred the last time Spurs played West Ham, 10 days ago, but he will get the night off with Paulo Gazzaniga due to deputise after he impressed in the shoot-out win over Watford in the previous round at Stadium MK on September 26.

When the Lilywhites faced the Hammers earlier this month, Tottenham triumphed 1-0 thanks to Erik Lamela’s first-half goal.

But West Ham boss Manuel Pellegrini doesn’t believe the result in the league will have any bearing on this fixture.

He said: “No, because it is a different competition and Tottenham will change most of the players from their normal starting XI because of the Monday game with City.

“We don’t have many players also so we will see for that game which are the better players to play.”