Spurs will be without Jan Vertonghen, Danny Rose, Eric Dier and Victor Wanyama at Wolves, but it could open the door for teenager Oliver Skipp

Mauricio Pochettino has some fresh injury worries ahead of Tottenham Hotspur’s trip to Wolverhampton Wanderers in the Premier League this weekend.

The Spurs boss knew he would be without Jan Vertonghen for the foreseeable future, with the centre back still on the road to recovery from a hamstring injury sustained in the win at Huddersfield Town on September 29.

In addition to the Belgian’s absence, the Lilywhites will also be missing Danny Rose, Eric Dier and Victor Wanyama at the Molineux.

Wanyama picked up a problem with his left knee during the 3-1 victory at West Ham United in the last-16 of the League Cup on Wednesday night.

It means he will be absent for the clash with Wolves and so will Dier and Rose, and the latest news on the pair is a big blow for Pochettino and Spurs.

The club have revealed the England internationals are “unlikely to return before the international break.”

It means Rose, who hasn’t played since the 1-0 win over Cardiff City on October 6, and Dier will not only miss Saturday’s game, but also Tuesday’s Champions League tie at home to PSV and the league fixture away to Crystal Palace on November 10.

Spurs left-back Rose is still unavailable with a groin injury, while the thigh issue Dier suffered in the 1-0 loss to Manchester City on Monday is set to keep him out for the next few weeks.

With Dier and Wanyama unavailable, the onus will fall on Mousa Dembele and Harry Winks to step up and produce the goods on Saturday.

There may also be a spot on the bench for talented youth-teamer Oliver Skipp, who made his Tottenham debut as a late substitute in the win at West Ham on Wednesday.

Skipp, 18, has been a regular in the Spurs under-23 team for over a year now and the youngster has impressed Pochettino over the last few months.

He was left out of Tottenham’s under-23s for the visit of Swansea City in the Premier League 2 today, which suggests he may be part of the travelling contingent to Wolves this weekend.